Author

Hiroshi Mitsumoto

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Open access Sep 2026

Astrocyte-derived extracellular vesicle phosphorylated TDP-43 as a blood-based biomarker for amyotrophic lateral sclerosis

Although the specificity of ADEV pTDP-43 relative to disease mimics and associations with disease progression require further investigation, these findings support its potential as a biomarker candidate for ALS and for patient stratification in TDP-43-targeted clinical trials.

Tanya H. Butt, Madeleine Strait, Lina Marcinczyk et al. · Neurobiology of Disease · 1 citation

Review Open access Aug 2026

ALS: An Organism-Wide Bioenergetic Failure Due to Mitochondrial Dysfunctions?

Targeting upstream mechanisms of mitochondrial impairment may provide a unifying strategy for understanding ALS pathogenesis and developing effective therapies.

Hiroshi Mitsumoto, H. Blasco, P. Corcia et al. · Biomolecules · 0 citations