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Author

Hiroshi Morioka

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Open access Aug 2026

Hydration Energetics Shape Antibody Discrimination between Sulfotyrosine and Phosphotyrosine

Chemically similar post-translational modifications can mediate distinct biological functions, but how proteins distinguish between them remains unclear. Sulfotyrosine (sTyr) and phosphotyrosine (pTyr) exemplify this problem because they have similar sizes, local geometries, and electrostatic properties but function in...

Takahiro Mori, Kota Yahagi, Saki Maruoka et al. · 0 citations
Open access Sep 2026

Somatic Hypermutations Enhance Neutralization Breadth of IGHV3‐53/3‐66 Public Antibodies Against SARS‐CoV‐2 Variants

This work assessed whether non‐broadly neutralizing IGHV3‐53/3‐66 antibodies could mature into broadly neutralizing antibodies and found some acquire broad neutralizing activity through accumulation of somatic hypermutations.

Takeo Kuwata, K. Okazaki, Hiroshi Morioka et al. · 0 citations

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