Author

Hirtotaka Iwaki

2 papers indexed here

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Open access Sep 2026

Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke

Introduction Ischemic stroke (IS) is a leading cause of morbidity and mortality, and predicting events remains challenging. Polygenic risk scores (PRSs) aggregate genetic variants, but performance varies across ancestries and remains modest, particularly in non-European populations. Methods We compared Bayesian PRS met...

N. Armstrong, V. Srinivasasainagendra, Amit Patki et al. · Frontiers in Bioinformatics · 0 citations

Open access Jul 2026

Genome-wide association studies identify genetic determinants of synucleinopathy biomarkers

Background α-Synucleinopathies are clinically and biologically heterogeneous disorders lacking reliable biomarkers to assist with early diagnosis, disease progression, patient stratification, and therapeutic targeting. Genetic variation is known to impact biomarker levels, influencing their utility and interpretation i...

E. Somerville, Lang Liu, Michael Ta et al. · Research Square · 0 citations