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Author

Hitomi Fujita

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Review Open access Sep 2026

[Pharmacological properties and clinical efficacy of bempedoic acid (NEXLETOL® tablets 180 mg) for the treatment of hypercholesterolemia].

Bempedoic acid (Nexletol®) is a novel cholesterol-lowering agent that is converted to its active CoA ester by very long-chain acyl-CoA synthetase 1 (ACSVL1), an enzyme selectively expressed in hepatocytes. The active metabolite selectively inhibits ATP citrate lyase (ACL), leading to a reduction in cytosolic acetyl-CoA...

Tomohisa Suzuki, Hitomi Fujita, Hiromi Maune · 0 citations

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