Open access
Jul 2026
Activity-dependent ribosome profiling reveals the landscape of canonical and non-canonical translation in brain tissue
A ribosome tagging and purification strategy is developed that bypasses the prolonged turnover of ribosomal proteins, enabling ribosome profiling with one-hour temporal resolution after neural stimulation, and uncovered previously unknown activity-dependent alternative translation with functional implication, such as the uORF of Egr1.
Nayan Suryawanshi, Hitoshi Uchida, R. Endo et al.
· Nature Communications · 0 citations