Hoang Duy Le

Tuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity

Self-amplifying RNA (saRNA) offers a powerful approach for vaccine development, as its replicative nature within cells provides prolonged antigen expression together with self-adjuvanticity. However, its potency is often limited by innate immune responses, particularly those triggered by intracellular double-stranded R...