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Author

Holger Hackstein

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Open access Sep 2026

The Factor VII mutation F7 c.760T>C (FVIIp.Cys254Arg) is causative for Factor VII deficiency by impairing secretion.

BACKGROUND Hereditary Factor VII (FVII) deficiency is a bleeding disorder caused by mutations in the F7 gene, a diagnosis that is complicated by a weak genotype-phenotype correlation. However, accurate pathogenicity assessment of FVII variants is essential for effective clinical management. OBJECTIVES Here, we report...

Malte M. Bartylla, Sarah Cunningham, S. Achenbach et al. · 0 citations
Open access Jan 2026

Development and Validation of a Multiplex Flow Cytometry‐Based PBMC Assay for Immunomodulator Screening

The identification of novel compounds capable of stimulating or suppressing immune responses is critical for advancing immunotherapy and improving our understanding of immune regulation. However, traditional screening approaches are often limited by low throughput, poor physiological relevance, and insufficient resolut...

Regine Brox, Holger Hackstein · 0 citations

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