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Hong-Bing Ma

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Open access Sep 2026

Prognostic Significance of Secondary‐Type Mutations in NPM1‐Mutated Acute Myeloid Leukemia

NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML), and NPM1‐mutated AML is generally associated with a favorable prognosis. However, substantial prognostic heterogeneity exists within this population. The prognostic significance of secondary‐type mutations (STMs) in NPM1‐mutated AML remain...

Kun Yang, Hongmei Luo, Bing Xiang et al. · 0 citations
Case report Open access Aug 2026

Ponatinib plus asciminib in myeloid blast-phase CML harboring a phased BCR::ABL1 Y253H/T315I compound mutation: a case report

A heavily pretreated patient with myeloid blast-phase CML in whom next-generation sequencing at blast transformation identified Y253H, T315I, and a low-level Y253_E255delinsHGK variant is reported, and phasing analysis demonstrated that Y253H and T315I were present on the same BCR::ABL1 allele, confirming a true compou...

Ying-Ying Hu, Hong-Bing Ma, Xu He · 0 citations

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