The ovary is among the earliest organs to show clinically consequential age-related decline. The luteinizing hormone/choriogonadotropin receptor (LHCGR) mediates the trophic actions of LH and human chorionic gonadotropin (hCG) in the ovary, and reduced receptor abundance has sometimes been invoked as a possible expla...
This review repositions theca cells as active, bidirectionally regulated participants in ovarian aging-integral to, rather than upstream of, the oocyte-granulosa-theca unit, and proposes theca-specific biomarkers and targeted interventions as priorities for future translational research.
Hong-Bo Wu, Zhao Zhang, Qian-Yi Huang et al.· Reproductive Biology and End...· 0 citations
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