Author

Hong-Bo You

3 papers indexed here

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Open access Aug 2026

Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration.

BACKGROUND Osteoarthritis (OA) is characterized by persistent inflammation, extracellular matrix (ECM) degradation, and impaired autophagy. Corilagin is a natural ellagitannin with anti-inflammatory properties, but its effects on OA remain unclear. METHODS IL-1β-stimulated primary mouse chondrocytes were used to eval...

Ruijiao Zhou, Jie Li, Sheng Chen et al. · International Immunopharmaco... · 0 citations

Aug 2026

Inhibition of PARP-1 attenuates osteoarthritis progression by suppressing NF-κB signaling and alleviating chondrocyte senescence.

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage destruction, inflammation, and chondrocyte senescence, yet no disease-modifying therapies are currently available. Poly(ADP-ribose) polymerase-1 (PARP-1) has been implicated in inflammation and aging, but its role in OA pathogenesi...

Rui Zhang, Lingying Wang, Wen-Bin Pei et al. · Cellular Signalling · 0 citations

Review Open access Jan 2026

Pathological Mechanisms of Tendinopathy Pain: From Mechanical Overload to Neuroimmune–Vascular Crosstalk

Characterized by localized pain and functional impairment, tendinopathy remains a significant challenge in sports medicine. Traditional models of structural degeneration and inflammation inadequately explain the clinical discordance between tissue damage and pain severity. This review explores the paradigm shift in und...

Chen-Yu He, Ai-Kang Li, Qing-Yi Liu et al. · Pain Research and Management · 0 citations