Author

Hongchuan Jin

3 papers indexed here

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Review Sep 2026

The cGAS-STING signaling in hepatocellular carcinoma: A spatiotemporally gated immune switch linking pro-tumorigenic immune evasion and anti-tumor therapeutic response.

Hepatocellular carcinoma (HCC) arises from chronic inflammation and immune tolerance, posing substantial challenges for immunotherapy. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling is a central immunological hub linking innate immune sensing to adaptive immune responses in tumors. In...

Yuan Chen, Yu-Hong An, Chao-Qun Wang et al. · Biochimica et biophysica act... · 0 citations

Open access Aug 2026

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance

Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking. Here, we investigated the dual role of ferredoxin 1 (FDX1) in modulating both multikinase inhibito...

Wei-Kai Wang, Xin Jiang, Xiaona Chen et al. · Cancer Communications · 0 citations

Review Jul 2026

A new chapter in precision medicine: Circulating tumor cells in breast cancer prognosis and treatment.

Breast cancer (BC) persists as a leading cause of cancer-related mortality among women globally. While the characterization of molecular subtypes has improved our understanding and precision treatment of the disease, the detection and analysis of circulating tumor cells (CTCs) offer a complementary, dynamic perspective...

Chentao Li, Miaoqin Chen, Zhuo Wang et al. · Biochimica et biophysica act... · 0 citations