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Author

Honghao Hou

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Open access Aug 2026

Lactylation-dependent DDX18 nucleolar escape regulates CD44 mRNA stability to drive fibrotic progression in kidney injury

It is demonstrated that lactate drives sustained renal damage through posttranslational lactylation of the RNA helicase DDX18, and protein lactylation is established as a regulatory mechanism governing RNA helicase nucleolar localization and subsequent control of mRNA stability, revealing a potential therapeutic target...

Li-Jun Dong, Jing-Wen Xie, Meng-Yuan Tao et al. · 0 citations

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