Author

Honghe Zhang

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Open access Aug 2026

Enhancer Collapse Dictates PKHD1 Silencing and Centrosome-Mediated Chromosomal Instability and Metastasis in Clear Cell Renal Cell Carcinoma.

Chromosomal instability (CIN) drives clear cell renal cell carcinoma (ccRCC) progression, yet its upstream triggers remain elusive. To identify key drivers governing renal genomic integrity, we integrated machine learning-driven screening with Mendelian randomization analysis to prioritize candidates associated with bo...

Yue-Yang Wang, Lingling Wang, Jingwen Deng et al. · Experimental Cell Research · 0 citations

Open access Jul 2026

Long noncoding RNA MNX1-AS1 mediated regulation of one-carbon metabolism by preventing CACYBP degradation to promote lung cancer progression.

It is established that the lncRNA MNX1-AS1 acts as a crucial driver of one-carbon metabolism reprogramming in non-small cell lung cancer and highlighted that the newly identified MNX1-AS1/CACYBP/β-catenin axis may serve as a potential prognostic biomarker and therapeutic target for lung cancer intervention.

Juze Yang, Xinyi Qian, Jiayi Ren et al. · Cell Death and Differentiati... · 0 citations