Osteosarcoma is an aggressive bone malignancy with a propensity for pulmonary metastasis, yet the molecular mechanisms linking protein homeostasis to epitranscriptomic regulation remain incompletely understood. Here, integrated transcriptomic, survival, protein-interaction, and CRISPR dependency analyses identified the...
Yan-Fei Wu, Li-Ping Ma, Zhao-Qi Chen et al.· Biochimica et Biophysica Act...· 0 citations
Intervertebral disc degeneration (IVDD) is a predominant contributor to low back pain, characterized by nucleus pulposus cell (NPC) senescence, extracellular matrix (ECM) metabolic dysfunction, and chronic inflammation. Excessive mitochondrial fission contributes to IVDD, yet the underlying regulatory mechanisms remain...
Pengfei Li, Yichen Que, Shuhao Zhang et al.· Cellular Signalling· 0 citations
Among adolescents worldwide, osteosarcoma (OS) is one of the most frequently occurring cancers. DSCAM‐AS1, a recognized lncRNA, has been noted for its abnormal expression in the development of certain cancers, but its role in OS is still unclear. Quantification of DSCAM‐AS1, miR‐211‐5p, and PDCD6 expression was carried...
Qi Wang, Yunzheng Zhao, Long-Bao Shi et al.· Drug development research (P...· 0 citations
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