Astrocyte-derived CXCL14 promotes oligodendrocyte differentiation and remyelination via ERK1/2 signaling: implications for multiple sclerosis therapeutics
Multiple sclerosis (MS) is a debilitating demyelinating disease of the central nervous system (CNS) in which progressive neurological disability is closely linked to the failure of endogenous remyelination. Reactive astrocytes are hallmarks of MS lesions, yet their functional role in myelin repair remains incomplet...