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Author

Hongjuan Cui

2 papers indexed here

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Review Open access Oct 2026

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance

Glioma is characterized by profound metabolic reprogramming and sustained lactate accumulation; however, the mechanisms by which lactate-rich metabolic stress is translated into stable malignant phenotypes remain incompletely understood. Lysine lactylation (Kla), a recently identified post-translational modification, h...

Xiao-Song Hu, Li Yang, Yang-Hao Hu et al. · 0 citations
Open access Sep 2026

β3GnT2-mediated N-glycosylation of EGFR and LDLR drives glioblastoma progression and can be targeted by AST-1306

Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a poor prognosis and limited therapeutic options. In this study, we identify β3GnT2 (β-1,3-N-acetylglucosaminyltransferase 2) as a critical driver of GBM progression and a potential therapeutic target. β3GnT2 is significantly upregulated...

Peng-Fei Shi, Jie Xu, Dandan Zhang et al. · 0 citations

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