The site-specific functionalization of therapeutic proteins and peptides represents a significant challenge in modern synthetic chemistry due to the presence of numerous competing nucleophilic residues. Conventional chemical conjugation strategies not only suffer from poor regioselectivity-leading to high product heter...
A unified annotation framework for topological and conformational descriptors is provided and HighDB is compared with representative cyclic peptide resources, showing broader annotation coverage and the largest collection of experimentally resolved cyclic peptide structures among the databases examined.
Yi-Qi Xu, Ning Zhu, Tianfeng Shang et al.· Journal of Computer-Aided Mo...· 0 citations
HighMorph is presented, an interaction-guided framework that combines protein–protein interaction information with artificial intelligence for rational cyclic peptide design and provides insights for developing therapeutics targeting challenging protein interfaces.
M. Lan, Cheng-Yun Zhang, Wentong Wang et al.· Journal of Medicinal Chemist...· 0 citations
HighPlay2 is presented as a feasible framework for the early-stage design and screening of cyclic peptide candidates containing ncAAs, while further affinity maturation and experimental structural validation remain necessary.
Huitian Lin, Wentong Wang, Ning Zhu et al.· European journal of medicina...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
