Author

Hong-Lin Li

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Review Sep 2026

Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS/MAM): Multi-Layered Upstream Regulators of Microglial Senescence in Alzheimer's Disease.

BACKGROUND Alzheimer's disease (AD) is an age-dependent neurodegenerative syndrome in which microglial senescence bridges biological ageing and Aβ-tau pathology. Senescent microglia undergo permanent cell-cycle arrest, upregulate p16INK4a and SA-β-gal, and secrete a pro-inflammatory senescence-associated secretory phen...

An-Nan Liu, Li-Ping Xing, Jian-Hui Li et al. · Ageing Research Reviews · 0 citations

Review Open access Aug 2026

Mitochondrial dysfunction-driven ferroptosis in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic strategies (Review)

A multidimensional pathological network composed of multiple mitochondrial abnormalities, including mitochondrial reactive oxygen species bursts, Ca2+ overload and disruption of the mitochondrial quality control system, synergistically amplifies lipid peroxidation and drives neuronal ferroptosis across the pathophysiol...

Jian-Hui Li, An-Nan Liu, Wei Gao et al. · Molecular Medicine Reports · 0 citations

Review Aug 2026

Pyroptosis in Alzheimer's disease: Mechanisms and neuroinflammatory networks.

Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.

Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al. · Molecular and cellular neuro... · 0 citations