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Hong-Ling Jia

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Open access Aug 2026

Single-cell transcriptomic landscape delineates pathogenic NK cell subpopulations and key mediators in systemic inflammatory response syndrome

Systemic inflammatory response syndrome (SIRS) carries high ICU morbidity, sepsis lacks standardized therapies, and stage-variable natural killer (NK) cell function in SIRS remains poorly defined due to insufficient single-cell evidence. Herein, we analyzed public LPS-induced SIRS peripheral blood single-cell RNA seq...

Hong-Ling Jia, Hang Zhao, Yan Li et al. · 0 citations
Review Open access Jul 2026

Diagnostic and therapeutic applications of melanoma-derived exosomes in nanomedicine

Melanoma remains challenging due to pronounced heterogeneity, early metastasis, and dynamic treatment resistance. Conventional tissue biopsy and imaging provide essential information but are limited by invasiveness, sampling bias, and an inability to capture longitudinal tumor-immune evolution. As endogenous bio-nanoma...

Li Li, Xin Zheng, Jingrui Shi et al. · 0 citations
Open access Aug 2026

Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer

This study identified UBE2C+ proliferative tumor cells as a functionally relevant malignant subpopulation in SCLC and links this state to immune-stromal communication networks within the tumor microenvironment and provides a systems-level framework for investigating the cancer-immunity regulome in SCLC.

Hong-Ling Jia, Yongxuan An, Bing Chen et al. · 0 citations

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