A robust high-throughput screening assay based on AMP-Glo™ and a library of blood–brain barrier–permeable compounds are developed, identifying five inhibitors spanning three distinct scaffolds with low micromolar potency that establish UBA5 as a tractable enzymatic target and provide first-in-class chemical tools to pr...
Vigyasa Singh, Yuansong Wan, Zhisong Gao et al.· ACS Chemical Biology· 0 citations
This review examines the principles and applications of target-based antiviral drug development against human respiratory viruses, emphasizing the identification and exploitation of conserved viral and host targets.
S. K. Samrat, Gaurie Srivastava, Ran Zhang et al.· Pathogens· 0 citations
The expression, purification, and enzymatic characterization of recombinant Mtb ADSS are reported, providing the first comprehensive biochemical framework for studying Mtb ADSS and establishing a foundation for structure-guided inhibitor discovery targeting purine biosynthesis as a novel antitubercular strategy.
Vigyasa Singh, Ran Zhang, Ke Chen et al.· Biochimica et Biophysica Act...· 0 citations
AlphaFold 3 (AF3) and Boltz-2 are state-of-the-art AI-based tools for biomolecular structure prediction, but whether their predictions provide useful guidance for lead optimization, SAR interpretation, and virtual screening remains insufficiently characterized. We benchmarked their performance using newly determined so...
Ke Chen, Zuo-Huang Qi, Omar Lozano Ramos et al.· bioRxiv· 0 citations
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