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Author

Hong-Qiang Qin

2 papers indexed here

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Oct 2026

Integrated N- and O-Glycoproteomics Reveals Site-Specific Glycosylation Dysregulation in Alzheimer’s Disease

Alzheimer’s disease (AD) remains a global health challenge, in part due to the lack of reliable blood-based biomarkers for early detection and disease monitoring. Protein glycosylation critically regulates the structure and function of circulating macromolecules, yet integrated site-specific evaluation of both N- and...

Zhuo Zhang, Yong-Shuang Zhang, Xu-Yang Yue et al. · 0 citations
Open access Oct 2026

Targeting mannosylation of nicastrin N-glycans attenuates γ-secretase activity and notch-dependent leukemia progression

γ-Secretase is a transmembrane protease complex that cleaves multiple type I transmembrane proteins, including amyloid precursor protein and neurogenic locus notch homolog protein (NOTCH). Although numerous γ-secretase inhibitors and modulators targeting Notch-dependent cancers have been developed in recent decades, th...

Hua Jiang, Wei-Xiang Bian, Yan-Jun Cao et al. · 0 citations

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