The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, classically recognized as a crucial cytosolic DNA-sensing mechanism in innate antiviral immunity, is now emerging as a pivotal regulator of sterile inflammation and immune dysregulation. Recent evidence has shifted the paradigm,...
Hong-Quan Wang, Zhi-Ji Wang, Wei-Hua Zheng et al.· International Immunopharmaco...· 0 citations
: The cGAS-STING pathway, a cornerstone of cytosolic DNA sensing, and necroptosis, a pro-inflammatory regulated cell death modality, are increasingly recognized as intimately interconnected axes that profoundly influence disease pathogenesis. This review synthesizes current knowledge on their bidirectional crosstalk, e...
Hong-Quan Wang, Zhi-Ji Wang, Hui Zhang et al.· Drug Design, Development and...· 0 citations
As a pivotal module of the innate immune system, the cGAS-STING signaling pathway is responsible for sensing cytosolic DNA and triggering inflammatory reactions, and it exerts a vital function in the pathological progression of hemorrhagic stroke.This review synthesizes current evidence on the involvement of cGAS-STING...
