Comparative efficacy and safety of B-cell-targeted biologics in systemic lupus erythematosus: a systematic review and network meta-analysis
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement and heterogeneous clinical manifestations. Aberrant B-cell activation and elevated levels of B-lymphocyte stimulator (BLyS) play a central role in its pathogenesis [1]. Several B-cell–targeted biologic agents hav...