Hong-Xia Li

The G-quadruplex ligand CX-5461 inhibits laryngeal cancer via inducing immunogenic cell death and remodeling the tumor immune microenvironment.

BACKGROUND AND OBJECTIVE G-quadruplex (G4) structures, formed by guanine-rich nucleic acids, are implicated in tumor progression and represent promising therapeutic targets. In laryngeal cancer, the profile and clinical relevance of G4s, as well as the efficacy of G4 ligands, remain unexplored. This study aims to exami...