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Hong-Xiang Wu

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Open access Sep 2026

Silver(I)-mediated amide-to-ester transformation on unprotected peptides for protein chemical synthesis and engineering

Chemical protein synthesis has transformed the preparation of homogeneous peptides and proteins with site-specific modifications. Serine/threonine ligation offers a practical route to access difficult peptides and proteins via its aggregation-breaking intermediate, yet the preparation and regeneration of the prerequisi...

Zhen-Quan Sun, Wai-Yin Yau, Hua-Jie Kang et al. · 0 citations

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