Hong-Xiang Yan

A four-gene signature identifies TKI-induced persister cells and uncovers a ZLN005-induced pyroptotic vulnerability via the GSDME pathway in EGFR-mutant lung cancer

Public transcriptomic datasets from tumour cell-based models treated with EGFR inhibitors or other targeted agents within the receptor tyrosine kinase (RTK)/RAS/MAPK pathway were integrated with machine-learning-based feature selection, survival analysis and Cancer Dependency Map-based pharmacogenomic screening to defi...