Author

Hong Xu

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Open access Sep 2026

Cyclopeptide 161 protects human dermal fibroblasts against UV-induced damage via the MEK1/2–ERK1/2 signaling pathway

Introduction Cutaneous homeostasis is constantly perturbed by ultraviolet (UV) irradiation, which triggers extracellular matrix (ECM) structural derangement, fibroblast senescence, and the gradual deterioration of dermal integrity. CP161, a synthetic cyclic hexapeptide, has been documented to upregulate the transcripti...

Yue Xiao, Xing-Ge Huang, Xiao Zhang et al. · Frontiers in Physiology · 0 citations

Open access Sep 2026

MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair.

A cell-based system to induce transient mitochondrial stress and resolve its recovery dynamics is established, which uncover a damage-sensing checkpoint that gates the decision between recovery and clearance, and reveal active and regulated pathways for mitochondrial repair.

Nuo Chen, Zhirong Li, Xiyuan Wang et al. · Cell Reports · 0 citations