Discovery of FM-604, a Benzyl-Substituted Pyrimidinedione PPO Inhibitor with Potent Postemergence Herbicidal Activity
Protoporphyrinogen IX oxidase (PPO) is a validated target for fast-acting herbicides. To identify low-dose PPO-inhibiting leads, 41 benzyl-substituted pyrimidinedione derivatives were designed by side-chain optimization of epyrifenacil and synthesized. In greenhouse postemergence screening, FM-604 provided 100% contr...