Mixed-phenotype acute leukemia (MPAL) is a rare hematological malignancy with poor prognosis, for which there are currently no standardized therapeutic guidelines. Preclinical and clinical studies have shown that venetoclax and BCR::ABL1 tyrosine kinase inhibitors have synergistic effects on Philadelphia chromosome–pos...
Xia Li, Yi-Le Zhou, Xiang-Jie Lin et al.· Blood Research· 0 citations
Myelofibrosis is a clonal myeloproliferative neoplasm characterized by progressive remodeling of the bone marrow microenvironment. Megakaryocyte (MK) abnormalities are defining histological features of prefibrotic and overt primary myelofibrosis and contribute to disease pathogenesis. Dysplastic MKs can directly modify...
Jian-Song Huang, Xiao-Yue Yin, Xiao-Feng Shi et al.· Biomarker Research· 0 citations
Myelodysplastic syndrome with biallelic TP53 inactivation (MDS-biTP53) patients represents an ultra-high-risk subgroup with dismal outcomes. Even after allogeneic hematopoietic stem cell transplantation (allo-HSCT), relapse rates remain extremely high and survival is poor. This preliminary case series reports the outco...
Yan-Ling Ren, W. Lang, Yu Xu et al.· Experimental Hematology & On...· 0 citations
Using mRNA sequencing, two novel fusion genes are identified and validated and it is proposed that the combination of these novel fusion genes, multiple SNVs, and the complex karyotype collectively contributed to the patient’s multidrug resistance.
Jifang Tu, Yungui Wang, Xiangli Gao et al.· Therapeutic Advances in Hema...· 0 citations
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