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Hong-Yan Wang

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Open access Sep 2026

ACTA2-directed actin filaments license STING trafficking and activation for antiviral immunity and autoimmune pathogenesis.

The cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is essential for antiviral immunity, and its dysregulation causes inflammatory disease. The mechanism underlying STING activation, including its essential endoplasmic reticulum-to-Golgi translocation, has remained elusive. Here, we identify a de...

Xian-Teng Hou, Qing Wu, Yang-Ting Du et al. · 0 citations

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