Hong-Yi Wu

CD147 drives acute-on-chronic liver failure progression by triggering hepatocyte PANoptosis.

Acute-on-chronic liver failure (ACLF) is an acute and severe syndrome with high mortality and limited therapeutic options. Excessive systemic inflammation, which drives hepatocyte dysfunction and programmed cell death, constitutes the hallmark feature of ACLF progression. PANoptosis, a coordinated form of apoptosis, ne...