Author

Hong-Yu Yang

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Oct 2026

Enzyme-Activated Cascade Biocatalysis of a Hyaluronic Acid-Engineered Biomineralization Nanozyme for Amplified Multimodal Cancer Treatment

The integration of nanozyme-based catalytic activity interventions within the tumor microenvironment (TME) with phototherapies represents a promising approach for triggering multimodal synergistic cancer therapy. Herein, a protein-mineralized nanozyme was fabricated via in situ biomineralization, utilizing iron ions...

Si-Qi Zhan, Moon-Sun Jang, Wei Jiang et al. · ACS Applied Polymer Material... · 0 citations

Sep 2026

CD44 Receptor-Guided Hyaluronic Acid Nanogels with Dual-Stimuli Responsiveness and Lysosomal Disruption Capability for In Vivo Protein Delivery in Lung Cancer Treatment

Protein delivery nanosystems must balance stable loading, barrier navigation, and targeted, controlled release. Herein, a pH/ROS dual-responsive nanogel (PRNG) was constructed by forming dynamic boronic ester crosslinkers between PEGylated hyaluronic acid bearing diethylenetriamine-grafted-catechol groups (PEG-HA-Die...

Wei Jiang, Wei Sun, Si-Qi Zhan et al. · Biomacromolecules · 0 citations

Jul 2026

Mesoporous CuS functionalized hydrogel with hierarchical structure for synergistic photothermal antibacterial activity, strong bioadhesion and accelerated hemostasis in wound repair.

A pioneering near-infrared activated antibacterial EPLGA/OHADA@HMCuS hydrogel was formulated by doping hollow mesoporous copper sulfide (HMCuS) into the three-dimensional spatial network structure formed between gallic acid-modified ε-polylysine (EPL-GA) and dopamine-engineered and oxidized hyaluronic acid (OHADA) and...

N. Wang, Wei Jiang, Feiyu Lu et al. · Biomaterials Advances · 0 citations