Hong-Yu Zhang

Trojan horse-inspired vaccine-like nanoparticle with enhanced lubrication and active-passive synergistic anti-inflammation for post-traumatic osteoarthritis treatment

Post-traumatic osteoarthritis (PTOA) is initiated by joint injury and progresses through the interaction of abnormal mechanical loading, oxidative stress, inflammation, and extracellular matrix degradation. Early intra-articular intervention is greatly limited by rapid clearance, insufficient lubrication, and dynamical...