Author

Hong-Yun Huang

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Open access Sep 2026

MetScore and classical–basal subtype intersect to define chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Background Transcriptomic heterogeneity in pancreatic ductal adenocarcinoma (PDAC) is conventionally modeled along a single classical–basal axis, but this framework incompletely explains clinical behavior. We hypothesized that MetScore, a single-sample measure of metastatic colonization potential, defines a complementa...

Raymond E. Preston, Hong-Yun Huang, Margaret A. Hall et al. · bioRxiv · 0 citations

Sep 2026

Abstract A028: Metastatic potential defines an orthogonal axis of transcriptomic heterogeneity that predicts chemotherapy response and tumor microenvironment architecture in pancreatic ductal adenocarcinoma

Metastatic cell state is established as an independent and clinically actionable dimension of PDAC biology that complements classical–basal subtype classification and will inform chemotherapy backbone choice in KRAS inhibitor trials, as well as treatment following progression on KRAS inhibitor monotherapy.

Raymond E. Preston, Hong-Yun Huang, Margaret A. Hall et al. · Cancer Research · 0 citations

Open access Aug 2026

Artificial intelligence-driven prediction and design of cell-penetrating peptides for advanced drug delivery system

An artificial intelligence-driven framework that integrates biochemical rules derived from large language models (LLMs) with conventional peptide descriptors for CPP prediction and design is developed and demonstrates that combining LLM-derived biochemical knowledge with machine learning improves interpretable CPP pred...

Bo Yu, Yue Lu, Ze-Ying Kuang et al. · Frontiers in Pharmacology · 0 citations