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Hong-Zhi Gao

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Open access Oct 2026

NOTCH1 and ADORA3 define a novel transdifferentiation-related prognostic index for prognostic stratification in glioblastoma by integrating clinical factors.

BACKGROUND/OBJECTIVES Glioblastoma (GBM) exhibits aggressive progression and poor prognosis, partly driven by glioma stem cell-endothelial transdifferentiation (GSC-ET), an alternative vascularization mechanism associated with therapeutic resistance. However, robust prognostic models based on transdifferentiation-relat...

Zong-Qing Zheng, Yi-Xiao Li, Yong-Xiang Zhang et al. · 0 citations
Open access Oct 2026

Clusterin interference decreases cerebral ischemia/reperfusion injury by suppressing TFR1-dependent ferroptosis.

Ferroptosis plays a crucial role in the pathological process of cerebral ischemia-reperfusion (I/R) injury, but the specific regulatory mechanism of Clusterin in this process remains unclear. This study aims to investigate whether interfering with Clusterin can alleviate cerebral I/R injury by regulating neuronal ferro...

Xiao-Ping Zhou, He-Lan Yuan, Wei-Long Huang et al. · 0 citations
Jul 2026

Di(2-ethylhexyl) Phthalate (DEHP) Exposure Exacerbates Subarachnoid Hemorrhage by Inducing Astrocyte-Mediated Inflammation and Oxidative Stress through the ADORA1/PI3K-Akt/MAPK Axis.

It is revealed that DEHP aggravates SAH neurotoxicity via ADORA1-mediated astrocyte inflammation and oxidative stress through the PI3K-Akt/MAPK axis, providing new insights into environmental pollutant neurotoxicity.

Shao-Jie Li, Baofang Wu, Jian-Jin Guo et al. · 0 citations

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