Hong Zhou

DNA Nanotube-Confined 3D Walker Enables Endogenous Dual-Activated AND Gate Imaging of Tumor-Associated piRNA

Intracellular molecular imaging for tumor biomarkers faces significant challenges in achieving high specificity and sensitivity, primarily due to signal leakage and the low abundance of target molecules. Herein, we develop an endogenous dual-activation sensing platform (termed E-DWRB) that integrates an AND logic gat...

Dual Amplification on Coordination-Engineered Photogate for Sensitive Organic Photoelectrochemical Transistor Biosensing.

MicroRNA (miRNA) analysis using organic photoelectrochemical transistor (OPECT) biosensors is often limited by insufficient photoelectric transduction efficiency and weak signal amplification. Herein, we develop a coordination heterojunction photogate-enabled OPECT biosensor combined with enzyme-free catalytic hairpin...

Programmable hairpin assembly circuit-cascaded DNAzyme amplification for ultrasensitive miRNA-146a detection via high-stable perovskite nanocomposite biosensor.