Review
Open access
Aug 2026
Alpha-ketoglutarate alleviates chronic kidney disease via mitochondrial protection, gut microbiota, and metabolite remodeling.
It is found that AKG ameliorated renal injury in CKD mice, attenuating inflammatory responses and fibrotic progression, and suggested that the nephroprotective effects of AKG against CKD could be mediated through the coordinated interplay of mitochondrial homeostasis, gut microbiota remodeling, and metabolic reprogramm...
Juan Xie, Hailun Li, Haijing Dou et al.
· Journal of Pharmaceutical an... · 0 citations