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Author

Hongmei Xie

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2 papers indexed here

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Open access Aug 2026

Dual Targeting of EGFR and HER2 by a Bispecific Antibody-Drug Conjugate Demonstrates Broad Antitumor Activity in Multiple Solid Tumors.

GenSci139, an EGFR×HER2 bispecific ADC, is developed and demonstrated superior antitumor efficacy over DS-8201 in multiple cell-line-derived xenograft and patient-derived xenograft models, suggesting potential for synergistic combination with immunotherapies.

Xiaojuan Chai, Fu Li, Hongmei Xie et al. · 0 citations
Open access Jul 2026

DEHP exposure induces cholesterol dysregulation and inflammatory signaling in human colonic epithelial cells: Implications for early colorectal carcinogenesis.

It is suggested that short-term DEHP exposure may disrupt intestinal epithelial homeostasis through a mechanism involving cholesterol transport impairment (SREBF1/ABCA1/ABCG1 axis), representing an early event in DEHP-associated colorectal pathogenesis.

Xinrui Zhou, Jiayi Diao, Jia-Min Lu et al. · 0 citations

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