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Author

Hongyan Tong

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4 papers indexed here

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Open access Oct 2026

Venetoclax combined with olverembatinib and prednisone as a frontline therapeutic strategy for Philadelphia chromosome-positive mixed-phenotype acute leukemia

Mixed-phenotype acute leukemia (MPAL) is a rare hematological malignancy with poor prognosis, for which there are currently no standardized therapeutic guidelines. Preclinical and clinical studies have shown that venetoclax and BCR::ABL1 tyrosine kinase inhibitors have synergistic effects on Philadelphia chromosome–pos...

Xia Li, Yi-Le Zhou, Xiang-Jie Lin et al. · 0 citations
Review Open access Sep 2026

Megakaryocytes in myelofibrosis: mechanisms of fibrotic niche remodeling and therapeutic implications

Myelofibrosis is a clonal myeloproliferative neoplasm characterized by progressive remodeling of the bone marrow microenvironment. Megakaryocyte (MK) abnormalities are defining histological features of prefibrotic and overt primary myelofibrosis and contribute to disease pathogenesis. Dysplastic MKs can directly modify...

Jian-Song Huang, Xiao-Yue Yin, Xiao-Feng Shi et al. · 0 citations
Open access Aug 2026

Sequential therapy with decitabine and an XPO-1 inhibitor followed by allogeneic hematopoietic stem cell transplantation in MDS with biallelic TP53 inactivation patients : a preliminary case series

Myelodysplastic syndrome with biallelic TP53 inactivation (MDS-biTP53) patients represents an ultra-high-risk subgroup with dismal outcomes. Even after allogeneic hematopoietic stem cell transplantation (allo-HSCT), relapse rates remain extremely high and survival is poor. This preliminary case series reports the outco...

Yan-Ling Ren, W. Lang, Yu Xu et al. · 0 citations
Case report Open access Aug 2026

Identification of novel UBE2E3::PDE1A and CTC1::MEF2C fusion transcripts in acute myeloid leukemia

Using mRNA sequencing, two novel fusion genes are identified and validated and it is proposed that the combination of these novel fusion genes, multiple SNVs, and the complex karyotype collectively contributed to the patient’s multidrug resistance.

Jifang Tu, Yungui Wang, Xiangli Gao et al. · 0 citations

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