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Author

Hongyu Zhao

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Open access Jul 2026

Cell-type-specific polygenic risk scores reveal adipocyte-related interactions with lipids in coronary artery disease

Cell-type-specific decomposition of genome-wide PRSs for CAD identified biologically distinct lipid interactions that were not captured by the genome-wide PRS, highlighting the potential of cell-type-informed PRSs to improve the biological interpretation of PRSs and provide insights into the heterogeneous mechanisms un...

Jia-Qi Hu, Le-Qi Xu, Tian-Yu Liu et al. · 0 citations

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