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Author

Hoon Ryu

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Open access Aug 2026

Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammation

The TAM receptor AXL is identified as a molecular transducer that couples Aβ sensing to the regulation of autophagy and neuroinflammation in astrocytes and proposed the AXL-ICD/SIRT2 axis as an effective therapeutic target to reduce Aβ burden and neuroinflammation in AD.

T. Kim, Mridula Bhalla, Uiyeol Park et al. · 0 citations
Open access Jul 2026

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

QA activates a microglia-specific signaling cascade that promotes PE biosynthesis and GAP, thereby enhancing Aβ clearance and mitigating AD pathology, and reveals a paradoxically beneficial role of QA in activating a microglia-specific signaling cascade that promotes PE biosynthesis and GAP.

Seung Jae Hyeon, Seungchan Kim, Jiyeon Chu et al. · 2 citations

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