Fused, Not Coated: The Protein Corona on Ionizable Lipid Nanoparticles, from Biophysical Curiosity to Clinical Design Parameter
No lipid nanoparticle (LNP) arrives in the body as the particle a chemist made. Within moments of entering a biological fluid, it is stripped of that designed identity and reclothed by the proteins and lipoproteins it collides with there, and it is this improvised second identity that interacts with biosystems and de...