Hossein Omidi Ardali

Regulation of Membrane Association and Downstream Effector Interaction of K-Ras by Its Hypervariable Region

The small GTPase Ras, a central switch in signal transduction of cell growth, is a crucial element in the development of many forms of cancer. Recent studies have shown that membrane association of Ras is essential to its downstream effector recruitment and signal transduction. Here we investigate the membrane associat...