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Hou-Jie Liu

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Open access Oct 2026

TOP2A Overexpression as a Prognostic Biomarker in High-Grade Meningioma: An Integrated Single-Cell and Bulk Transcriptomic Study

By integrating transcriptional overexpression with copy-number gain, this study identifies TOP2A mRNA and protein overexpression as a prognostic biomarker in high-grade meningioma and shows that focal TOP2A copy-number gain is enriched in high-grade tumors and concordant with TOP2A expression.

Hong-Qing Cai, Guan-Chao Xie, Hou-Jie Liu et al. · 0 citations

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