Houbing Zhang

Primary amine-functionalized radially amphiphilic polypeptides target bacterial phospholipids in polyanionic matrices for biofilm therapy.

Bacterial biofilm infections, a key contributor to antibiotic resistance, pose a critical global health challenge. Although antimicrobial peptides are promising candidates, their cationic amphipathic structures often lead to nonspecific sequestration by polyanionic biofilm matrix components. Here, we report a class of...