Muscle relaxation is enabled by the sarco-endoplasmic reticulum Ca2+-ATPase (SERCA), which removes calcium from the cytosol and returns it to the lumen of the sarcoplasmic reticulum. During transport, SERCA adopts a variety of conformational states which differ in their structure and affinity for substrates. The transi...
Joseph O. Primeau, M. Lemieux, Paul LaPointe et al.· Journal of Membrane Biology· 0 citations
A covalent pan-coronaviral inhibitor that targets 19 Mpros across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses, AVI8122 exhibits low nanomolar potency and favorable pharmacokinetics in mice and is positioned as an early lead compound and a tractable structural starting point for th...
Pu Chen, Ulrike Strunk, E. Arutyunova et al.· Journal of Medicinal Chemist...· 0 citations
CD-nMS is established, alone or in combination with SLOMO, as a broadly applicable assay for quantitative characterization of complex biomolecular interactions across soluble, glycosylated, and membrane-associated systems.
Ziyu Zhang, D. Bui, Ling Han et al.· Analytical Chemistry· 0 citations
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