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Hsing-Fan Lai

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Open access Aug 2026

Ibrutinib-triggered matriptase maintains extracellular CD19 and limits antigen escape in B-cell malignancy

CD19-directed CART therapy has improved outcomes in B-cell malignancies, but durable responses remain limited by antigen escape, in which loss of surface CD19 can drive antigen-negative relapse. Ibrutinib (IB) has been reported to enhance CART activity, yet whether IB directly modulates tumor-cell antigen presentatio...

Xin-Jie Lu, Hsing-Fan Lai, Yu-Sin Hung et al. · 0 citations

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