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Hua-Chuan Wen

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Sep 2026

Structure-guided evolution of Marinobacter subterrani deacetylase for enhanced herbicide precursor synthesis by substrate-binding pocket and channels engineering.

Deacetylases can directly hydrolyze amide bonds for the environmentally friendly synthesis of the herbicide intermediate O-(3-chloro-2-propenyl)hydroxylamine. However, the rigid halogenated chain of N-[(E)-3-chloroprop-2-enoxy]acetamide (NECA) may hinder productive substrate positioning and limit catalytic efficiency....

Yin-Feng Huang, Dian-Ju Wei, Hua-Chuan Wen et al. · 0 citations

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