Skeletal muscle repair after injury depends on a tightly coordinated cascade of inflammatory and regenerative responses. Damage-associated molecular patterns (DAMPs) link tissue damage to innate immune activation, but their effects are highly context dependent. This review summarizes the major cellular sources of DAMPs...
Zi-Hui Gao, Xia Li, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
Abstract Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous and fatal neurodegenerative disorder, for which clinical management and drug development have long faced formidable challenges. Since the approval of riluzole and edaravone, dozens of promising drug candidates that showed efficacy in preclinical mod...
Yutong Wei, Jie Wang, Ya-Nan Ji et al.· Drug Design, Development and...· 0 citations
Post-traumatic stress disorder (PTSD) is a profound neurobiological disorder in which dysregulation of the neuroendocrine system represents a core pathophysiological feature. This Review synthesizes recent advances in PTSD neuroendocrine research to delineate a comprehensive and dynamic pathological landscape that exte...
Xia Li, Yanbei Zhu, Ya-Nan Ji et al.· Biochemical Pharmacology· 0 citations
Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...
Yun-Tian Shen, Haiyan Jiang, Jie Wang et al.· Biochemical Pharmacology· 0 citations
The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.
Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al.· European Journal of Pharmaco...· 4 citations
The cGAS-STING pathway has emerged as a central hub linking kidney injury to inflammation, metabolism, and fibrosis, and its precise modulation holds transformative therapeutic promise for hundreds of millions of patients with kidney diseases worldwide.
Guang-Dong Qi, Fei Xue, Hua-Lin Sun et al.· Frontiers in Pharmacology· 3 citations
A novel perspective on the inflammatory mechanisms underlying diabetes mellitus and its complications is provided, thereby establishing a theoretical foundation for the development of therapeutic strategies centered on modulating the cGAS-STING pathway.
Guang-Dong Qi, Tong-Xin Shang, Hua-Lin Sun et al.· Frontiers in Pharmacology· 0 citations
BACKGROUND AND PURPOSE
The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...
Boya Liu, Fei Xue, Xingxing Fang et al.· British Journal of Pharmacol...· 0 citations
This review systematically examines the mechanisms of major PDBIs in hypertension, focusing on their regulation of vascular function, renin-angiotensin-aldosterone system and sympathetic nervous system, water-salt homeostasis, and target organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan et al.· Phytotherapy Research· 0 citations
The composition and function of the m6A modification system is summarized, with a focus on its critical roles in skeletal muscle physiology, including satellite cell fate determination, myofiber differentiation and fusion, and energy homeostasis, and the molecular mechanisms by which m6A network dysregulation contribut...
Jie Wang, Haiyan Jiang, Jiacheng Sun et al.· Naunyn-Schmiedeberg's Archiv...· 1 citation
This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.
Haiyan Jiang, Zhanzhan Li, Xia Li et al.· Frontiers in Pharmacology· 2 citations
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