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Review Aug 2026

Beyond necroptosis: structural determinants, context-dependent non-canonical functions, and precision therapeutic targeting of RIPK3.

Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...

Yun-Tian Shen, Haiyan Jiang, Jie Wang et al. · 0 citations
Aug 2026

Tectorigenin protects against muscle atrophy from in vitro nutrient deprivation and in vivo denervation by activating the AMPK/SIRT1/PGC-1α pathway.

BACKGROUND AND PURPOSE The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...

Boya Liu, Fei Xue, Xingxing Fang et al. · 0 citations

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